报告题目：Photo-nano-immunotherapy for cancer treatment

报告人：Prof.Wei R.Chen（美国中央俄克拉荷马州立大学）

报告时间：2019年12月24日下午15:00开始

报告地点：国家科技园阳光楼一楼学术报告厅

个人简介：

Wei R. Chen, Professor, Dean at the Colleges of Mathematics and Science, University of Central Oklahoma. His main research interests include laser-tissue interactions, laser photothermal treatment of cancer, anti-tumor immune responses induced by laser treatment, simulation of light transport in tissues, and monitoring of cancer treatment using magnetic resonance imaging, photoacoustic imaging, X-ray imaging, IR thermal imaging, and other modalities. Dr. Chen is co-inventor of the novel immunoadjuvant, glycated chitosan. He is also the co-inventor of the novel cancer treatment method, laser immunotherapy (also named inCVAX), using laser irradiation and immunological stimulation.  Laser Immunotherapy has been used in initial clinical trials for late-stage, metastatic melanoma and breast cancer patients with promising outcomes. Dr. Chen had published more than 120 peer-reviewed articles and 150 conference proceeding papers.  He has been awarded eight US patents and several international patents.

报告摘要：

Cancer has been a leading cause of death since the beginning of human history. Various therapies have been developed, yet cancer remains to be one of the biggest medical challenges for researchers and practitioners. In an attempt to target the root cause of cancer, we developed laser immunotherapy (LIT). LIT aims at eradicating cancers by enlisting the help of the host immune system through a local intervention. It uses the combination of laser phototherapy and immunotherapy to induce tumor-specific immune responses.  In our pre-clinical and preliminary clinical studies, LIT is shown to be highly effective against metastatic tumors. The experimental results indicated a systemic, long-term anti-tumor immunological response induced by LIT, using the entire tumor cell as the sources of tumor antigens, based on the principle of in situ autologous whole-cell cancer vaccination. To further improve LIT, we developed laser-nanotechnology-based novel therapy using immunologically modified nanotubes to provide synergistic, synchronized photothermal and immunological interactions for cancer treatment. This talk will introduce to the audience the development of LIT, its preliminary clinical results, and the development of photo-nano-immunotherapy.