教育工作经历

2019-至今      学院，闽江学者特聘教授

2016-2019     美国国立卫生研究院（NIH），博士后

2011-2016     学院，博士

教学简介

主要承担硕士研究生课程《高等分析化学实验》、本科生课程《无机与分析化学C》。

科研简介

主要从事化学成像、纳米医学等方面研究工作，共发表论文50余篇，被引8000余次，H因子45。以第一/通讯作者发表论文20篇，包括J. Am. Chem. Soc.（2）、Angew. Chem. Int. Ed.（5）、Adv. Mater.（2）、ACS Nano（2）、Adv. Funct. Mater.（3）、Adv. Sci.（1）等，其中2篇入选ESI热点论文，7篇入选ESI高被引论文。

社会兼职

科研项目

1. 国家自然科学基金面上项目，65万元，在研，主持。

2. 福建省“闽江学者”特聘教授项目，200万元，结题，主持。

3. 国家重点研发计划纳米科技专项，895万元，在研，参与。

代表性论文

1. Meili Yu, Zhuangjie Ye, Siqin Liu, Yang Zhu, Xuegang Niu, Jun Wang, Rujiang Ao, Hongwei Huang, Huilan Cai, Yina Liu, Xiaoyuan Chen*, Lisen Lin*. Redox-Active Ferrocene Quencher-Based Supramolecular Nanomedicine for NIR-II Fluorescence-Monitored Chemodynamic Therapy. Angew. Chem. Int. Ed. 2024, 10.1002/anie.202318155.

2. Yang Zhu, Peng Gong, Jun Wang, Junjie Cheng, Wenyu Wang, Huilan Cai, Rujiang Ao, Hongwei Huang, Meili Yu, Lisen Lin,* Xiaoyuan Chen*. Amplification of Lipid Peroxidation by Regulating Cell Membrane Unsaturation To Enhance Chemodynamic Therapy. Angew. Chem. Int. Ed. 2023, 62, e202218407. (ESI高被引论文)

3. Jun Wang, Hongye Ding, Yang Zhu, Yina Liu, Meili Yu, Huilan Cai, Rujiang Ao, Hongwei Huang, Peng Gong, Yaxin Liao, Zhaolin Chen, Lisen Lin,* Xiaoyuan Chen,* Huanghao Yang*. Iron-siRNA Nanohybrids for Enhanced Chemodynamic Therapy via Ferritin Heavy Chain Downregulation. Angew. Chem. Int. Ed. 2023, 62, e202302255.

4. Tao Chen, Peidong Hou, Yafei Zhang, Rujiang Ao, Lichao Su, Yifan Jiang, Yuanli Zhang, Huilan Cai, Jun Wang, Qiushui Chen, Jibin Song, Lisen Lin*, Huanghao Yang*, Xiaoyuan Chen*. Singlet Oxygen Generation in Dark-Hypoxia by Catalytic Microenvironment-Tailored Nanoreactors for NIR-II Fluorescence-Monitored Chemodynamic Therapy. Angew. Chem. Int. Ed. 2021, 60, 15006-15012.

5. Li-Sen Lin, Jibin Song, Liang Song, Kaimei Ke, Yijing Liu, Zijian Zhou, Zheyu Shen, Juan Li, Zhen Yang, Wei Tang, Gang Niu, Huang-Hao Yang*, Xiaoyuan Chen*. Simultaneous Fenton-like Ion Delivery and Glutathione Depletion by MnO₂-Based Nanoagent to Enhance Chemodynamic Therapy. Angew. Chem. Int. Ed. 2018, 57, 4902-4906. (ESI热点论文, ESI高被引论文)

6. Lisen Lin, Sheng Wang, Hongzhang Deng, Weijing Yang, Lang Rao, Rui Tian, Yuan Liu, Guocan Yu, Zijian Zhou, Jibin Song, Huang-Hao Yang, Zhi-Yi Chen,* Xiaoyuan Chen*. Endogenous Labile Iron Pool-Mediated Free Radical Generation for Cancer Chemodynamic Therapy. J. Am. Chem. Soc. 2020, 142, 15320-15330. (ESI高被引论文)

7. Li-Sen Lin, Tao Huang, Jibin Song, Xiang-Yu Ou, Zhangtong Wang, Hongzhang Deng, Rui Tian, Yijing Liu, Jun-Feng Wang, Yuan Liu, Guocan Yu, Zijian Zhou, Sheng Wang*, Gang Niu, Huang-Hao Yang, Xiaoyuan Chen*. Synthesis of Copper Peroxide Nanodots for H₂O₂ Self-Supplying Chemodynamic Therapy. J. Am. Chem. Soc. 2019, 141, 9937-9945. (ESI热点论文, ESI高被引论文)

8. Li-Sen Lin, Jibin Song*, Huang-Hao Yang*, Xiaoyuan Chen*. Yolk-Shell Nanostructures: Design, Synthesis, and Biomedical Applications. Adv. Mater. 2018, 30, 1704639.

9. Li-Sen Lin, Xiangyu Yang, Zijian Zhou, Zhen Yang, Orit Jacobson, Yijing Liu, Angela Yang, Gang Niu, Jibin Song*, Huang-Hao Yang*, Xiaoyuan Chen*. Yolk-Shell Nanostructure: An Ideal Architecture to Achieve Harmonious Integration of Magnetic-Plasmonic Hybrid Theranostic Platform. Adv. Mater. 2017, 29, 1606681.

10. Yang Zhu, Wenyu Wang, Peng Gong, Yafei Zhao, Yuanbo Pan, Jianhua Zou, Rujiang Ao, Jun Wang, Huilan Cai, Hongwei Huang, Meili Yu, Huijuan Wang, Lisen Lin,* Xiaoyuan Chen,* Yuen Wu*. ACS Nano 2023, 17, 3064-3076. (ESI高被引论文)

11. Li-Sen Lin, Zhong-Xiao Cong, Jian-Bo Cao, Kai-Mei Ke, Qiao-Li Peng, Jinhao Gao, Huang-Hao Yang*, Gang Liu*, Xiaoyuan Chen. Multifunctional Fe₃O₄@Polydopamine Core-Shell Nanocomposites for Intracellular mRNA Detection and Imaging-Guided Photothermal Therapy. ACS Nano 2014, 8, 3876-3883. (ESI高被引论文)

12. Tao Chen, Zhaolin Chen, Qianting Zhou, Hongye Ding, Peng Gong, Jun Wang, Huilan Cai, Rujiang Ao, Meili Yu, Jibin Song, Lisen Lin,* Huanghao Yang*. Microenvironment-Tailored Catalytic Nanoprobe for Ratiometric NIR-II Fluorescence/Photoacoustic Imaging of H₂O₂ in Tumor and Lymphatic Metastasis. Adv. Funct. Mater. 2022, 32, 2208720.

13. Xuegang Niu, Yang Zhu,* Chenyu Ding, Jing Ma, Penghui Wei, Yuanxiang Lin, Wenhua Fang, Qiu He, Chunwang Li, Junjie Cheng, Jianhua Zou, Lisen Lin,* Xiaoyuan Chen,* Dezhi Kang*. Dual-Active Center AgFeCu Nanocatalyst for Tumor Destruction via Self-Catalytically Enhanced Mild Photothermal Therapy. Adv. Funct. Mater. 2023, 2306778.

14. Rong Zhu, Juan Li, Lisen Lin*, Jibin Song*, and Huanghao Yang*. Emerging Plasmonic Assemblies Triggered by DNA for Biomedical Applications. Adv. Funct. Mater. 2021, 31, 2005709.

15. Sheng Wang, Guocan Yu, Weijing Yang, Zhantong Wang*, Orit Jacobson, Rui Tian, Hongzhang Deng, Lisen Lin*, Xiaoyuan Chen*. Photodynamic-Chemodynamic Cascade Reactions for Efficient Drug Delivery and Enhanced Combination Therapy. Adv. Sci. 2021, 8, 2002927. (ESI高被引论文)

获奖情况

2020 福建省自然科学一等奖（第四完成人）

2020 福建省引进高层次B类人才

2018 福建省“闽江学者奖励计划”特聘教授

其他