杨凯
日期:2022-10-11 阅读次数: 作者: 来源:






           

姓 名:

杨凯

性 别:

职 称:

副研究员/博士生导师

学 历:

博士

电 话:


专 业:

有机化学

电子邮件:

kyang@fzu.edu.cn

研究方向:

有机硼化学




IMG_257教育工作经历

  2020.11~至今 学院,皇冠国际体育app,副研究员

  2018.09~2020.10 学院,皇冠国际体育app,博士后

  2013.09~2018.06 华侨大学,化工学院,博士  

  2009.09~2013.06 南华大学,药学院,学士


教学简介


科研简介

  致力于发展高效、高选择性和普适的方法合成手性有机硼化合物,并探索这类化合物在医药、催化以及材料化学等领域的应用,以及探索硼原子的引入对反应和手性化合物性质的影响。将有机硼化学与手性化学有机结合起来,是我们未来重点关注与研究的方向。


社会兼职


科研项目

 (1) 国家自然科学基金面上项目(2023-2026) 

 (2) 国家自然科学基金青年基金(2021-2023)

 (3) 福建省自然科学基金青创项目(2022-2025)


代表性论文

20.Wang, H.; Qiao, B.; Zhu, J.; Guo, H.; Zhang, Z.; Yang, K.*Li, S.-J.; Lan, Y.*; Song, Q.* Enantio- and Regioselective [2 + 2 + 2] Cycloaddition of BN-Diynes for Construction of C-B Axial Chirality. Chem 2023, DOI: 10.1016/j.chempr.2023.09.017.


19.Xu, J.; Qiu, W.; Zhang, X.; Wu, Z.; Zhang, Z.; Yang, K.*; Song, Q.* Palladium‐Catalyzed Atroposelective Kinetic C−H Olefination and Allylation for the Synthesis of C−B Axial Chirality. Angew. Chem. Int. Ed. 2023, 62, e202313388.


18. Yang, K.Mao,Y.# Zhang, Z.Xu, J.; Wang, H.; He,Y.;  Yu, P.*; Song, Q.* Construction of C-B axial chirality via dynamic kinetic asymmetric cross-coupling mediated by tetracoordinate boron, Nat. Commun. 202314, 4438.


17. Wang, C.; Zhou, L.; Qiu, J.; Yang, K.*; Song, Q.* Rh-Catalyzed diastereoselective addition of arylboronic acids to α-keto N-tert-butanesulfinyl aldimines: synthesis of α-amino ketones. Org. Chem. Front. 2022, 9, 1016-1022.


16. Xu, H.; Ye, M.; Yang, K.*; Song, Q.* Regioselective Cross-Coupling of Isatogens with Boronic Acids to Construct 2,2-Disubstituted Indolin-3-one Derivatives. Org. Lett. 2021, 23, 7776-7780.


15. Yang, K.; Mao, Y.; Xu. J.; He, Y.; Li, W.; Song, Q.* Construction of axially chiral arylborons via atroposelective miyaura borylation. J. Am. Chem. Soc. 2021, 143, 10048-10053.


14. Yang, K.; Song, Q.* Tetracoordinate boron intermediates enable unconventional transformations. Acc. Chem. Res. 2021, 54, 2298-2312.

13. Yang, K.; Zhang, F.; Fang, T.; Li, C.; Li, W.; Song, Q.* Passerini-type reaction of boronic acids enables α-hydroxyketones synthesis. Nat. Commun. 2021, 12, 441.


12. Yang, K.; Hu, X., Li, W.; Qiu, J.; Feng, Q.; Wang, S.; Zhang, G.; Kuang, Z.; Yu, P.*; Song, Q.* Transition-metal-free double insertive coupling of isocyanides with arylboronic acids enabled diarylmethanamines. Cell Rep. Phys. Sci. 2020, 1, 100268.


11. Yang, K.; Kuang, Z.; Song, Q.* Radical-induced 1,2-boron shift, enabling 1,3-difunctionalization of allylboronic esters. Chem, 2020, 6, 330-331.

10. Yang, K.; Lou, Y.; Wang, C.; Qi, L.-W.; Fang, T.; Zhang, F.; Xu, H.; Zhou, L.; Li, W.; Zhang, G.; Yu, P.*; Song, Q.* Chiral brønsted acid from chiral phosphoric acid boron complex and water: asymmetric reduction of indoles. Angew. Chem. Int. Ed. 2020, 59, 3294-3299.


9. Yang, K.; Zhang, F.; Fang, T.; Zhang, G.; Song, Q.* Stereospecific 1,4-metallate shift enables stereoconvergent synthesis of ketoximes. Angew. Chem. Int. Ed. 2019, 58, 13421–13426.


8. Yang, K.; Zhang, G.; Song, Q.* Four-coordinate triarylborane synthesis via cascade B–Cl/C–B cross-metathesis and C–H bond borylation. Chem. Sci. 2018, 9, 7666-7672.


7. Yang, K.; Song, Q.* Transition-metal-free regioselective synthesis of alkylboronates from arylacetylenes and vinyl arenes. Green Chem. 2016, 18, 932-936.

6. Yang, K.; Ke, M.; Lin, Y.; Song, Q.* Sulfonamide formation from sodium sulfinates and amines or ammonia under metal-free conditions at ambient temperature. Green Chem. 2015, 17, 1395-1399.

5. Yang, K.; Song, Q.* Pd-Catalyzed Regioselective Arylboration of Vinylarenes. Org. Lett. 2016, 18, 5460−5463.

4. Yang, K.; Song, Q.*. Fe-Catalyzed Double Cross-Dehydrogenative Coupling of 1,3-Dicarbonyl Compounds and Arylmethanes Org. Lett. 2015, 17, 548-551.

3. Yang, K.; Zhou, F.; Kuang, Z.; Gao, G.; Driver, T. G.; Song, Q.* Diborane-Mediated Deoxygenation of oNitrostyrenes To Form Indoles. Org. Lett. 2016, 18, 4088-4091.

2. Yang, K.; Song, Q.* Palladium-Catalyzed Arylboration of Bicyclic Alkenes. J. Org. Chem. 2016, 81, 1000-1005.

1. Yang, K.; Song, Q.* Styryl ether formation from benzyl alcohols under transition-metal-free basic DMSO conditions. Org. Biomol. Chem. 2015, 13, 2267-2272.



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